Authorities issued a province-wide dangerous persons alert early that morning, but by the afternoon extended the alert to neighbouring provinces Alberta and Manitoba.
Police have said that some of the victims were targeted, while others appeared to have been randomly attacked.
The stabbings happened at multiple locations, including James Smith Cree Nation and Weldon in Saskatchewan.
Police told reporters they are expecting more victims, with some injured people transporting themselves to various hospitals.
A manhunt is now underway after police named Damien Sanderson and Myles Sanderson as the two suspects.
More to come.
The Briefing serves up the latest news headlines and a deep dive into a topic affecting you. Hosted by Tom Tilley and co-hosts Katrina Blowers, Antoinette Lattouf, Rhianna Patrick and Jamila Rizvi. Published Monday to Saturday at 6am for a thorough briefing on the news of the day. Hear it on the Listnr App.